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pentobarbital will lessen the level or result of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to some decrease in fentanyl plasma concentrations, lack of efficacy or, maybe, growth of a withdrawal syndrome in a very affe